The epigenetic reader SntB regulates secondary metabolism, development and global histone modifications in Aspergillus flavus.

ABSTRACT: Due to the role, both beneficial and harmful, that fungal secondary metabolites play in society, the study of their regulation is of great importance. Genes for any one secondary metabolite are contiguously arranged in a biosynthetic gene cluster (BGC) and subject to regulation through the remodeling of chromatin. Histone modifying enzymes can place or remove post translational modifications (PTM) on histone tails which influences how tight or relaxed the chromatin is, impacting transcription of BGCs. In a recent forward genetic screen, the epigenetic reader SntB was identified as a transcriptional regulator of the sterigmatocystin BGC in A. nidulans, and regulated the related metabolite aflatoxin in A. flavus. In this study we investigate the role of SntB in the plant pathogen A. flavus b

SUBMITTER: Pfannenstiel BT 

PROVIDER: S-EPMC6215504 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature