Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients with Graves' Orbitopathy.

ABSTRACT:

Purpose

Intravenous methylprednisolone (IVMP) pulse therapy is the first-line treatment in active moderate-to-severe Graves' orbitopathy (GO) and dysthyroid optic neuropathy (DON). One of the adverse effects of this therapy is liver dysfunction that can be mild (ALT < 100 U/L), moderate (ALT: 100-300 U/L), and severe defined as acute liver injury (ALI) (ALT > 300 U/L). ALI can be irreversible and fatal. The aim of the study was to evaluate the influence of two different schemes of therapy with IVMP in moderate-to-severe GO and DON on biochemical liver parameters.

Materials and methods

49 patients with moderate-to-severe GO were treated with IVMP in every week schedule (cumulative dose 4.5 g), and 19 patients with DON received 3.0 g IVMP (1.0 g/day for 3 consecutive days). AS

SUBMITTER: Miskiewicz P 

PROVIDER: S-EPMC6215562 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature