Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation.

ABSTRACT:

Background

p130 Crk-associated substrate (p130CAS; also known as BCAR1) is a scaffold protein that modulates many essential cellular processes such as cell adhesion, proliferation, survival, cell migration, and intracellular signaling. p130Cas has been shown to be highly expressed in a variety of human cancers of epithelial origin. However, few data are available regarding the role of p130Cas during normal epithelial development and homeostasis.

Methods

To this end, we have generated a genetically modified mouse in which p130Cas protein was specifically ablated in the epidermal tissue.

Results

By using this murine model, we show that p130Cas loss results in increased cell proliferation and reduction of cell adhesion to extracellular matrix. In addition, epidermal dele

SUBMITTER: Camacho Leal MDP 

PROVIDER: S-EPMC6215608 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature