DNA methylation levels are associated with CRF₁ receptor antagonist treatment outcome in women with post-traumatic stress disorder.

ABSTRACT:

Background

We have previously evaluated the efficacy of the CRF₁ receptor antagonist GSK561679 in female PTSD patients. While GSK561679 was not superior to placebo overall, it was associated with a significantly stronger symptom reduction in a subset of patients with probable CRF system hyperactivity, i.e., patients with child abuse and CRHR1 SNP rs110402 GG carriers. Here, we test whether blood-based DNA methylation levels within CRHR1 and other PTSD-relevant genes would be associated with treatment outcome, either overall or in the high CRF activity subgroup.

Results

Therefore, we measured CRHR1 genotypes as well as baseline and post-treatment DNA methylation from the peripheral blood in the same cohort of PTSD-diagnosed women treated with GSK561679 (N = 43) or

SUBMITTER: Pape JC 

PROVIDER: S-EPMC6215613 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature