Are the indications for postoperative radiotherapy in the NCCN guidelines for patients with gastric adenocarcinoma too broad? A study based on the SEER database.

ABSTRACT:

Background

The types of patients with gastric adenocarcinoma (GA) for whom postoperative radiotherapy can improve the disease-specific survival rate (DSS) remain controversial. This study aims to explore the ideal indications.

Methods

Patients in the Surveillance, Epidemiology, and End Results (SEER) database with T3-4Nx or TxN+ GA from January 1988 to December 2012 were included and divided into a postoperative chemoradiotherapy group (Group R) and a postoperative chemotherapy group (Group C). We established a nomogram to predict DSS and then divided entire patient cohort into low-risk and high-risk groups based on the DSS predicted by the nomogram.

Results

The Cox multiple regression analysis demonstrated that various risk factors affected DSS for Group R. Based on

SUBMITTER: Huang ZN 

PROVIDER: S-EPMC6215633 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature