βcatenin is a marker of poor clinical characteristics and suppressed immune infiltration in testicular germ cell tumors.

ABSTRACT:

Background

WNT/βcatenin (WNTβ) pathway is activated in early stages of embryonic development. We aimed to evaluate the significance of βcatenin in germ cell tumors (GCTs) and explore associations with the inflamed environment.

Methods

Surgical specimens from 247 patients were analyzed. Βcatenin expression was detected in the tumor tissue by immunohistochemistry and correlated with clinical characteristics, outcome, PD-L1 expression and systemic immune-inflammation index (SII). The Ingenuity Pathway Analysis (IPA) was used to investigate the immune-cell related effects of βcatenin and PD-L1 encoding genes.

Results

βcatenin was expressed in 86.2% of GCTs. The expression in seminomas was significantly lower compared to all subtypes of non-seminoma (all P <  0.0001). A hi

SUBMITTER: Chovanec M 

PROVIDER: S-EPMC6215644 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature