Altered Treg and cytokine responses in RSV-infected infants.

ABSTRACT:

Background

Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and pneumonia in children under 1 y of age in the USA. The host immune response is believed to contribute to RSV-induced disease. We hypothesize that severe RSV infection in infants is mediated by insufficient regulation of the host immune response of regulatory T cells (Tregs) resulting in immunopathology.

Methods

Blood and nasal aspirates from 23 RSV-infected and 17 control infants under 1 y of age were collected. Treg frequencies were determined by flow cytometry from peripheral blood mononuclear cells. Analysis of 24 cytokines was measured by multiplex assay on nasal aspirates.

Results

We demonstrate that the frequency of activated Tregs is significantly reduced in the peripheral bl

SUBMITTER: Christiaansen AF 

PROVIDER: S-EPMC6215710 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature