Ontology highlight
ABSTRACT:
SUBMITTER: Kuzmin E
PROVIDER: S-EPMC6215713 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20180401 6386
To systematically explore complex genetic interactions, we constructed ~200,000 yeast triple mutants and scored negative trigenic interactions. We selected double-mutant query genes across a broad spectrum of biological processes, spanning a range of quantitative features of the global digenic interaction network and tested for a genetic interaction with a third mutation. Trigenic interactions often occurred among functionally related genes, and essential genes were hubs on the trigenic network. ...[more]