Executive Function and Spatial Cognition Mediate Psychosocial Dysfunction in Major Depressive Disorder.

ABSTRACT: Background: Cognitive and psychosocial dysfunction are prevalent and disabling features of Major Depressive Disorder (MDD). Emerging evidence suggests that poor cognitive functioning mediates the negative effect of MDD on psychosocial function. However, there is a lack of research examining the domain-specific nature of this relationship. The current study evaluated whether the relationship between MDD and specific psychosocial subdomains (e.g., autonomy, occupational functioning) was mediated by domain-specific cognitive deficits. Methods: Data from 155 participants was obtained from the Cognitive Function and Mood Study (CoFaMS), a cross-sectional analysis of mood, cognition, social cognition, and functioning in individuals with MDD. Cognitive functioning was assessed (Curr

SUBMITTER: Knight MJ 

PROVIDER: S-EPMC6215806 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature