Comparative mutational evaluation of multiple lung cancers by multiplex oncogene mutation analysis.

ABSTRACT: In patients presenting with synchronous or metachronous multiple lung cancer (MLC), it is important to distinguish between multiple primary lung cancer (MP) and intrapulmonary metastasis (IM). The present study was aimed at investigating the mutational profiles of synchronous/metachronous MLC and to compare the classification of paired tumors by multiplex gene mutation analysis with the histopathological evaluation. We carried out targeted sequencing of 20 lung cancer-related oncogenes using next-generation sequencing (NGS) in 82 tumors from 37 MLC patients who underwent surgical resection at our department. The patients were diagnosed as MP or IM cases based on the Martini and Melamed criteria, histopathological and gene mutational evaluations. Matching mutations between paired tumors was

SUBMITTER: Takahashi Y 

PROVIDER: S-EPMC6215894 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature