Validation Study of an Operational Tolerance Signature in Korean Kidney Transplant Recipients.

ABSTRACT: Operational tolerance (OT), defined as maintaining stable graft function without immunosuppression after transplant surgery, is an ideal goal for kidney transplant recipients (KTRs). Recent investigations have demonstrated the distinctive features of B cells, T cells, and dendritic cell-related gene signatures and the distributions of circulating lymphocytes in these patients; nonetheless, substantial heterogeneities exist across studies. This study was conducted to determine whether previously reported candidate gene biomarkers and the profiles of lymphocyte subsets of OT could be applied in Korean KTRs. Peripheral blood samples were collected from 153 patients, including 7 operationally tolerant patients. Quantitative real-time PCR and flow cytometry were performed to evaluate gene expre

SUBMITTER: Lee YH 

PROVIDER: S-EPMC6215901 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature