Non-secreting pituitary tumours characterised by enhanced expression of YAP/TAZ.

ABSTRACT: Tumours of the anterior pituitary can manifest from all endocrine cell types but the mechanisms for determining their specification are not known. The Hippo kinase cascade is a crucial signalling pathway regulating growth and cell fate in numerous organs. There is mounting evidence implicating this in tumour formation, where it is emerging as an anti-cancer target. We previously demonstrated activity of the Hippo kinase cascade in the mouse pituitary and nuclear association of its effectors YAP/TAZ with SOX2-expressing pituitary stem cells. Here, we sought to investigate whether these components are expressed in the human pituitary and if they are deregulated in human pituitary tumours. Analysis of pathway components by immunofluorescence reveals pathway activity during normal human pituit

SUBMITTER: Xekouki P 

PROVIDER: S-EPMC6215911 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature