Human pancreatic α- to β-cell area ratio increases after type 2 diabetes onset.

ABSTRACT:

Aims/introduction

Pancreatic α-cell area and the α- to β-cell area ratio (α/β) might be associated with glucose tolerance. The aim was to clarify how these histological parameters change as glucose tolerance deteriorates.

Materials and methods

We analyzed pancreatic tissues obtained from pancreatectomies of 43 patients. We evaluated the relationships between α-cell area or the α/β and various clinical parameters. Additionally, we analyzed α-cell proliferation and the expression patterns of various pancreatic transcription factors.

Results

The α/β in individuals with longstanding (previously diagnosed) type 2 diabetes (0.36 ± 0.12) was higher than that in those with normal glucose tolerance (0.18 ± 0.10; P < 0.01), impaired glucose tolerance (0.17 ± 0.12; P < 0.05) and

SUBMITTER: Fujita Y 

PROVIDER: S-EPMC6215948 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature