Multimodal neuroimaging study of cerebrovascular disease, amyloid deposition, and neurodegeneration in Alzheimer's disease progression.

ABSTRACT:

Introduction

Cerebrovascular disease (CVD) is not currently considered a core pathological feature of Alzheimer's disease (AD), but mounting evidence suggests that concurrent CVD may exacerbate AD progression. The purpose of this study was first to examine the relationship among amyloid, CVD, and neurodegeneration and second to examine the extent to which amyloid and CVD pathology drive subsequent neurodegeneration over time.

Methods

Six hundred eight (224 normal controls, 291 mild cognitive impairment, 93 AD) subjects from the Alzheimer's Disease Neuroimaging Initiative with longitudinal AV45 positron emission tomography imaging and MR imaging were investigated.

Results

Amyloid and white matter hyperintensity (WMH) burden increased across clinical diagnosis groups (n

SUBMITTER: Lao PJ 

PROVIDER: S-EPMC6215981 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature