The Pathogenesis of Atherosclerosis Based on Human Signaling Networks and Stem Cell Expression Data.

ABSTRACT: Atherosclerosis is a common and complex disease, whose morbidity increased significantly. Here, an integrated approach was proposed to elucidate systematically the pathogenesis of atherosclerosis from a systems biology point of view. Two weighted human signaling networks were constructed based on atherosclerosis related gene expression data of stem cells. Then, 37 candidate Atherosclerosis-risk Modules were detected using four kinds of permutation tests. Five Atherosclerosis-risk Modules (three Absent Modules and two Emerging Modules) enriched in functions significantly associated with disease genes were identified and verified to be associated with the maintenance of normal biological process and the pathogenesis and development of atherosclerosis. Especially for Atherosclerosis-risk Emer

SUBMITTER: Li W 

PROVIDER: S-EPMC6216023 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature