Three Single Nucleotide Polymorphisms of LOXL1' in a Turkish Population with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.

ABSTRACT:

Objectives

To investigate the three single nucleotide polymorphisms (SNPs) (rs3825942, rs1048661, and rs2165241) of the LOXL1 gene in pseudoexfoliation syndrome (XFS) and pseudoexfoliation glucoma (XFG) in the Turkish population.

Materials and methods

DNA was obtained from blood samples of 48 XFS, 58 XFG, and 171 control subjects. Three LOXL1 SNPs (rs3825942, rs1048661, rs2165241) were investigated with real time PCR, a probe-based genotyping method, and melting curve analysis.

Results

All three SNPs of LOXL1 were significantly associated with XFS (rs3825942 p=3.54x10^-6, odds ratio [OR]=∞; rs1048661 p=0.008, OR=2.18; rs2165241 p=8.69x10^-9, OR=4.30) and XFG (rs3825942 p=3.41x10^-7, OR=∞; rs1048661 p=1.75x10^-5

SUBMITTER: Yaz Y 

PROVIDER: S-EPMC6216538 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature