Extraordinary Genome Instability and Widespread Chromosome Rearrangements During Vegetative Growth.

ABSTRACT: The haploid genome of the pathogenic fungus Zymoseptoria tritici is contained on "core" and "accessory" chromosomes. While 13 core chromosomes are found in all strains, as many as eight accessory chromosomes show presence/absence variation and rearrangements among field isolates. The factors influencing these presence/absence polymorphisms are so far unknown. We investigated chromosome stability using experimental evolution, karyotyping, and genome sequencing. We report extremely high and variable rates of accessory chromosome loss during mitotic propagation in vitro and in planta Spontaneous chromosome loss was observed in 2 to >50% of cells during 4 weeks of incubation. Similar rates of chromosome loss in the closely related Zymoseptoria ardabiliae suggest tha

SUBMITTER: Moller M 

PROVIDER: S-EPMC6216587 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature