A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

ABSTRACT: Body mass index (BMI), a proxy measure for obesity, is determined by both environmental (including ethnicity, age, and sex) and genetic factors, with > 400 BMI-associated loci identified to date. However, the impact, interplay, and underlying biological mechanisms among BMI, environment, genetics, and ancestry are not completely understood. To further examine these relationships, we utilized 427,509 calendar year-averaged BMI measurements from 100,418 adults from the single large multiethnic Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. We observed substantial independent ancestry and nationality differences, including ancestry principal component interactions and nonlinear effects. To increase the list of BMI-associated variants before assessing other differences,

SUBMITTER: Hoffmann TJ 

PROVIDER: S-EPMC6216593 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature