Assessment of a mouse xenograft model of primary colorectal cancer with special reference to perfluorooctane sulfonate.

ABSTRACT: Colorectal cancer ranks third among the most commonly diagnosed cancers in the United States. Current therapies have a range of side effects, and the development of a reliable animal model to speed the discovery of safe effective preventative therapies would be of great value. A cross-sectional study in a large Appalachian population recently showed an association between low circulating levels of perfluorooctane sulfonate (PFOS) and a reduced prevalence of colorectal cancer. A study using APC_min (C57BL/6J-Apc^Min/J) mice prone to familial adenomatous polyposis found PFOS was protective when exposure occurred during tumor development. To test the possible benefit of PFOS on spontaneous colorectal cancer, we developed a mouse model utilizing primary patient colorectal c

SUBMITTER: Wimsatt JH 

PROVIDER: S-EPMC6216948 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature