Targeted imaging and inhibition of triple-negative breast cancer metastases by a PDGFRβ aptamer.

ABSTRACT: While the overall mortality for breast cancer has recently declined, management of triple-negative breast cancer (TNBC) is still challenging because of its aggressive clinical behavior and the lack of targeted therapies. Genomic profiling studies highlighted the high level of heterogeneity of this cancer, which comprises different subtypes with unique phenotypes and response to treatment. Platelet-derived growth factor receptor β (PDGFRβ) is an established mesenchymal/stem cell-specific marker in human glioblastoma and, as recently suggested, it may uniquely mark breast cancer cells with stem-like characteristics and/or that have undergone epithelial-mesenchymal transition. Methods: Immunohistochemical analysis for PDGFRβ expression was performed on a human TNBC tissue microarray. F

SUBMITTER: Camorani S 

PROVIDER: S-EPMC6217067 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature