Microbubble-Mediated Enhanced Delivery of Curcumin to Cervical Cancer Cells.

ABSTRACT: The major bottleneck in the current chemotherapy treatment of cancer is the low bioavailability and high cytotoxicity. Targeted delivery of drug to the cancer cells can reduce the cytotoxicity and increase the bioavailability. In this context, microbubbles are currently being explored as drug-delivery vehicles to effectively deliver drug to the tumors or cancerous cells. Microbubbles when used along with ultrasound can enhance drug uptake and inhibit the growth of tumor cells. Several potential anticancer molecules exhibit poor water solubility, which limits their use in therapeutic applications. Such poorly water soluble molecules can be coadministered with microbubbles or encapsulated within or loaded on the microbubbles surface, to enhance the effectiveness of these molecules against ca

SUBMITTER: Upadhyay A 

PROVIDER: S-EPMC6217580 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature