Albumin Abundance and Its Glycation Status Determine Hemoglobin Glycation.

ABSTRACT: Diabetes diagnosis and management majorly depend upon the measurement of glycated hemoglobin (HbA1c) levels. Various factors influence HbA1c levels such as the use of various analytical methods and the presence of various clinical conditions. Plasma albumin levels were known to be negatively associated with HbA1c. However, the precise mechanism by which they affect HbA1c is not well understood. Therefore, we have studied the influence of albumin levels and its glycation status on hemoglobin glycation using erythrocyte culture experiments. Erythrocytes maintained at low albumin concentration exhibited relatively increased albumin and hemoglobin glycation as compared to that in those maintained at higher albumin concentration. Increase in albumin glycation may decrease its ability to protect

SUBMITTER: Jagadeeshaprasad MG 

PROVIDER: S-EPMC6217588 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature