Oral squamous carcinoma cells promote macrophage polarization in an MIF-dependent manner.

ABSTRACT:

Background

Tumor-associated macrophages (TAMs) are important determinants of intratumoral immune evasion, neoangiogenesis, extracellular matrix remodeling and dysregulated tumor cell proliferation. Our prior studies revealed that macrophage-derived, but not tumor cell-derived, macrophage migration inhibitory factor (MIF), is an important determinant of TAM alternative activation and M2 polarization.

Aim

Because MIF is historically thought to initiate signaling via a receptor-dependent, outside-in mode of action, we wished to investigate the specific contributions of tumor-derived vs. macrophage-derived MIF to M2 marker expression during macrophage polarization.

Design

Murine oral squamous cell-carcinoma cells (SCCVII) were co-cultured with either the RAW 264.7 mouse m

SUBMITTER: Barbosa de Souza Rizzo M 

PROVIDER: S-EPMC6217709 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature