HLA and KIR Associations of Cervical Neoplasia.

ABSTRACT:

Background

Cervical cancer is the fourth most common cancer in women, and we recently reported human leukocyte antigen (HLA) alleles showing strong associations with cervical neoplasia risk and protection. HLA ligands are recognized by killer immunoglobulin-like receptors (KIRs) expressed on a range of immune cell subsets, governing their proinflammatory activity. We hypothesized that the inheritance of particular HLA-KIR combinations would increase cervical neoplasia risk.

Methods

Here, we used HLA and KIR dosages imputed from single-nucleotide polymorphism genotype data from 2143 cervical neoplasia cases and 13858 healthy controls of European decent.

Results

The following 4 novel HLA alleles were identified in association with cervical neoplasia, owing to their link

SUBMITTER: Bao X 

PROVIDER: S-EPMC6217726 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature