TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity.

ABSTRACT:

Background

Obesity exerts negative effects on brain health, including decreased neurogenesis, impaired learning and memory, and increased risk for Alzheimer's disease and related dementias. Because obesity promotes glial activation, chronic neuroinflammation, and neural injury, microglia are implicated in the deleterious effects of obesity. One pathway that is particularly important in mediating the effects of obesity in peripheral tissues is toll-like receptor 4 (TLR4) signaling. The potential contribution of TLR4 pathways in mediating adverse neural outcomes of obesity has not been well addressed. To investigate this possibility, we examined how pharmacological inhibition of TLR4 affects the peripheral and neural outcomes of diet-induced obesity.

Methods

Male C57BL6/J mice

SUBMITTER: Moser VA 

PROVIDER: S-EPMC6217784 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature