Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic?

ABSTRACT:

Objective

A subset of children with febrile status epilepticus (FSE) are at risk for development of temporal lobe epilepsy later in life. We sought a noninvasive predictive marker of those at risk that can be identified soon after FSE, within a clinically realistic timeframe.

Methods

Longitudinal T₂ -weighted magnetic resonance imaging (T₂ WI MRI) of rat pups at several time points after experimental FSE (eFSE) was performed on a high-field scanner followed by long-term continuous electroencephalography. In parallel, T₂ WI MRI scans were performed on a 3.0-T clinical scanner. Finally, chronic T₂ WI MRI signal changes were examined in rats that experienced eFSE and were imaged months later in adulthood.

Results

Epilepsy-predi

SUBMITTER: Curran MM 

PROVIDER: S-EPMC6217797 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature