General synthesis of silica-based yolk/shell hybrid nanomaterials and in vivo tumor vasculature targeting.

ABSTRACT: Multifunctional yolk/shell-structured hybrid nanomaterials have attracted increasing interest as theranostic nanoplatforms for cancer imaging and therapy. However, because of the lack of suitable surface engineering and tumor targeting strategies, previous research has focused mainly on nanostructure design and synthesis with few successful examples showing active tumor targeting after systemic administration. In this study, we report the general synthetic strategy of chelator-free zirconium-89 (⁸⁹Zr)-radiolabeled, TRC105 antibody-conjugated, silica-based yolk/shell hybrid nanoparticles for in vivo tumor vasculature targeting. Three types of inorganic nanoparticles with varying morphologies and sizes were selected as the internal cores, which were encapsulated into single

SUBMITTER: Chen F 

PROVIDER: S-EPMC6217832 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature