Once vs twice-daily abacavir and lamivudine in African children.

ABSTRACT:

Background

Antiretroviral therapy (ART) adherence is critical for successful HIV treatment outcomes. Once-daily dosing could improve adherence. Plasma concentrations of once-daily vs twice-daily abacavir + lamivudine are bioequivalent in children, but no randomized trial has compared virological outcomes.

Methods

Children taking abacavir + lamivudine-containing first-line regimens twice daily for more than 36 weeks in the ARROW trial (NCT02028676, ISRCTN24791884) were randomized to continue twice-daily vs move to once-daily abacavir + lamivudine (open-label). Co-primary outcomes were viral load suppression at week 48 (12% noninferiority margin, measured retrospectively) and lamivudine or abacavir-related grade 3/4 adverse events.

Results

Six hundred and sixty-nine chi

SUBMITTER: Musiime V 

PROVIDER: S-EPMC6217915 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature