The preterm infant stomach actively degrades milk proteins with increasing breakdown across digestion time.

ABSTRACT: AIM:This study investigated the effect of time post-ingestion on gastric digestion and gastric hormones after feeding preterm infants unfortified and fortified human milk. METHODS:Human milk and infant gastric samples were collected from 14 preterm (23-32 weeks birth gestational age) mother-infant pairs within 7-98 days postnatal age. Gastric samples were collected one, two and three hours after beginning of feeding. Samples were analysed for pH, proteolysis, general protease activity and the concentrations of pepsin, gastrin and gastrin-releasing peptide (GRP). One-way ANOVA with repeated measures followed by Tukey's multiple comparisons test was used. RESULTS:Gastric pH was significantly decreased after each hour in the preterm infant stomach from one to three hours postprandial. Proteol

SUBMITTER: Demers-Mathieu V 

PROVIDER: S-EPMC6217957 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature