Low Coronary Wall Shear Stress Is Associated With Severe Endothelial Dysfunction in Patients With Nonobstructive Coronary Artery Disease.

ABSTRACT:

Objectives

This study investigated the relationship between low wall shear stress (WSS) and severe endothelial dysfunction (EDFx).

Background

Local hemodynamic forces such as WSS play an important role in atherogenesis through their effect on endothelial cells. The study hypothesized that low WSS independently predicts severe EDFx in patients with coronary artery disease (CAD).

Methods

Forty-four patients with CAD underwent coronary angiography, fractional flow reserve, and endothelial function testing. Segments with >10% vasoconstriction after acetylcholine (Ach) infusion were defined as having severe EDFx. WSS, calculated using 3-dimensional angiography, velocity measurements, and computational fluid dynamics, was defined as low (<1 Pa), intermediate (1 to 2.5 Pa),

SUBMITTER: Kumar A 

PROVIDER: S-EPMC6217963 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature