Repeat elements organise 3D genome structure and mediate transcription in the filamentous fungus Epichloe festucae.

ABSTRACT: Structural features of genomes, including the three-dimensional arrangement of DNA in the nucleus, are increasingly seen as key contributors to the regulation of gene expression. However, studies on how genome structure and nuclear organisation influence transcription have so far been limited to a handful of model species. This narrow focus limits our ability to draw general conclusions about the ways in which three-dimensional structures are encoded, and to integrate information from three-dimensional data to address a broader gamut of biological questions. Here, we generate a complete and gapless genome sequence for the filamentous fungus, Epichloë festucae. We use Hi-C data to examine the three-dimensional organisation of the genome, and RNA-seq data to investigate how Epichloë genome s

SUBMITTER: Winter DJ 

PROVIDER: S-EPMC6218096 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature