ICR suckling mouse model of Zika virus infection for disease modeling and drug validation.

ABSTRACT:

Background

Zika virus (ZIKV) infection causes diseases ranging from acute self-limiting febrile illness to life-threatening Guillain-Barré Syndrome and other neurological disorders in adults. Cumulative evidence suggests an association between ZIKV infection and microcephaly in newborn infants. Given the host-range restrictions of the virus, a susceptible animal model infected by ZIKV must be developed for evaluation of vaccines and antivirals. In this study, we propose a convenient mouse model for analysis of neurological disorders caused by ZIKV.

Methodology

Six-day-old immunocompetent ICR suckling mice were used in the experiment. Different inoculum virus concentrations, challenge routes, and challenge times were assessed. Viremic dissemination was determined in the liver

SUBMITTER: Wu YH 

PROVIDER: S-EPMC6218097 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature