Changes in Lean Muscle Mass Associated with Neoadjuvant Platinum-Based Chemotherapy in Patients with Muscle Invasive Bladder Cancer.

ABSTRACT:

Background

Baseline sarcopenia or severe lean muscle deficiency is independently associated with increased mortality after cystectomy for muscle-invasive urothelial carcinoma of the bladder (MIUC). The impact of chemotherapy on muscle mass in MIUC patients remains undefined.

Objectives

To describe preoperative changes in body composition in MIUC patients receiving platinum-based neoadjuvant chemotherapy (NC).

Methods

Patients with cT2-4 N0-1 M0 UC of the bladder who received NC were identified. Lumbar skeletal muscle index (SMI, cm²/m²), visceral adipose index (VAI, cm²/m²), and the subcutaneous and intramuscular adipose index (SAI, cm²/m²) were calculated using validated methodology (cross sectional ar

SUBMITTER: Rimar KJ 

PROVIDER: S-EPMC6218112 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature