Transcription factor KLF13 inhibits AKT activation and suppresses the growth of prostate carcinoma cells.

ABSTRACT:

Background

Krüppel-like factor 13 (KLF13), a member of the KLF family, is involved in the development of immunological diseases and tumor progression. However, the expression patterns and potential functions of KLF13 in prostate carcinoma are still unknown. Here, we aimed to study the roles and mechanisms of KLF13 in prostate cancer.

Methods

The expression levels of KLF13 was detected by Immunohistochemistry in prostate tumor tissues and the paired non-tumor tissues. The effects of KLF13 up-regulation was tested by performing CCK8, cell colon formation, flow cytometric analysis and measurement of tumor proliferation in nude mice. Signaling pathway was analyzed by Western blot.

Results

The current study, for the first time, found that KLF13 was downregulated in prostat

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6218114 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature