Ontology highlight
ABSTRACT:
SUBMITTER: Kelley DZ
PROVIDER: S-EPMC6218276 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Translational research : the journal of laboratory and clinical medicine 20180726
We have recently performed the characterization of alternative splicing events (ASEs) in head and neck squamous cell carcinoma, which allows dysregulation of protein expression common for cancer cells. Such analysis demonstrated a high ASE prevalence among tumor samples, including tumor-specific alternative splicing in the GSN gene.In vitro studies confirmed that overall expression of either ASE-GSN or wild-type GSN (WT-GSN) isoform inversely correlated with cell proliferation, whereas the high ...[more]