Sustained versus instantaneous connectivity differentiates cognitive functions of processing speed and episodic memory.

ABSTRACT: Synchrony of brain activity over time describes the functional connectivity between brain regions but does not address the temporal component of this relationship. We propose a complementary method of analysis by introducing the width of cross-correlation curves between functional MRI (fMRI) time series as a metric of the relative duration of synchronous activity between brain regions, or "sustained connectivity". Using resting-state fMRI, cognitive, and demographics data from 1,003 subjects included in the Human Connectome Project, we find that sustained connectivity is a reproducible trait in individuals, heritable, more transient in females, and shows changes with age in early adulthood. Sustained connectivity in sensory brain regions is specifically associated with differences in proce

SUBMITTER: King JB 

PROVIDER: S-EPMC6218279 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature