Resting-state functional connectivity of subcortical locomotor centers explains variance in walking capacity.

ABSTRACT: Walking capacity influences the quality of life and disability in normal aging and neurological disease, but the neural correlates remain unclear and subcortical locomotor regions identified in animals have been more challenging to assess in humans. Here we test whether resting-state functional MRI connectivity (rsFC) of midbrain and cerebellar locomotor regions (MLR and CLR) is associated with walking capacity among healthy adults. Using phenotypic and MRI data from the Nathan Kline Institute Rockland Sample (n =119, age 18-85), the association between walking capacity (6-min walk test distance) and rsFC was calculated from subcortical locomotor regions to 81 other gait-related regions of interest across the brain. Additional analyses assessed the independence and specificity of the resul

SUBMITTER: Boyne P 

PROVIDER: S-EPMC6218296 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature