Mechanisms and Role of Dendritic Membrane Trafficking for Long-Term Potentiation.

ABSTRACT: Long-term potentiation (LTP) of excitatory synapses is a major form of plasticity for learning and memory in the central nervous system. While the molecular mechanisms of LTP have been debated for decades, there is consensus that LTP induction activates membrane trafficking pathways within dendrites that are essential for synapse growth and strengthening. Current models suggest that key molecules for synaptic potentiation are sequestered within intracellular organelles, which are mobilized by synaptic activity to fuse with the plasma membrane following LTP induction. While the identity of the factors mobilized to the plasma membrane during LTP remain obscure, the field has narrowly focused on AMPA-type glutamate receptors. Here, we review recent literature and present new experimental data

SUBMITTER: Hiester BG 

PROVIDER: S-EPMC6218485 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature