Early movement restriction leads to maladaptive plasticity in the sensorimotor cortex and to movement disorders.

ABSTRACT: Motor control and body representations in the central nervous system are built, i.e., patterned, during development by sensorimotor experience and somatosensory feedback/reafference. Yet, early emergence of locomotor disorders remains a matter of debate, especially in the absence of brain damage. For instance, children with developmental coordination disorders (DCD) display deficits in planning, executing and controlling movements, concomitant with deficits in executive functions. Thus, are early sensorimotor atypicalities at the origin of long-lasting abnormal development of brain anatomy and functions? We hypothesize that degraded locomotor outcomes in adulthood originate as a consequence of early atypical sensorimotor experiences that induce developmental disorganization of sensorimotor

SUBMITTER: Delcour M 

PROVIDER: S-EPMC6218548 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature