TPH2 Deficiency Influences Neuroplastic Mechanisms and Alters the Response to an Acute Stress in a Sex Specific Manner.

ABSTRACT: Dysregulations of the central serotoninergic system have been implicated in several psychopathologies, characterized by different susceptibility between males and females. We took advantage of tryptophan hydroxylase 2 (TPH2) deficient rats, lacking serotonin specifically in the brain, to investigate whether a vulnerable genotype can be associated with alterations of neuronal plasticity from the early stage of maturation of the brain until adulthood. We found a significant increase, in both gene and protein expression, of the neurotrophin brain-derived neurotrophic factor (BDNF), in the prefrontal cortex (PFC) of adult TPH2-deficient (TPH2^-/-) male and female rats in comparison to wild type (TPH2^+/+) counterparts. Interestingly, a development-specific pattern was obser

SUBMITTER: Brivio P 

PROVIDER: S-EPMC6218558 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature