Adenosinergic Signaling Alters Natural Killer Cell Functional Responses.

ABSTRACT: Adenosine is a potent immunosuppressive purine metabolite contributing to the pathogenesis of solid tumors. Extracellular adenosine signals on tumor-infiltrating NK cells to inhibit their proliferation, maturation, and cytotoxic function. Cytokine priming imparts upon NK cells distinct activation statuses, which modulate NK anti-tumor immunity and responses to purinergic metabolism. Here, for the first time, we investigated human NK cell responses to adenosinergic signaling in the context of distinct cytokine priming programs. NK cells were shown to be hyper-responsive to adenosine when primed with IL-12 and IL-15 compared to IL-2, exhibiting enhanced IFN-γ expression from CD56^bright and CD56^dim subsets while modulating the expression of activation marker NKG2D. These

SUBMITTER: Chambers AM 

PROVIDER: S-EPMC6218627 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature