Understanding the Hidden Complexity of Latin American Population Isolates.

ABSTRACT: Most population isolates examined to date were founded from a single ancestral population. Consequently, there is limited knowledge about the demographic history of admixed population isolates. Here we investigate genomic diversity of recently admixed population isolates from Costa Rica and Colombia and compare their diversity to a benchmark population isolate, the Finnish. These Latin American isolates originated during the 16^th century from admixture between a few hundred European males and Amerindian females, with a limited contribution from African founders. We examine whole-genome sequence data from 449 individuals, ascertained as families to build mutigenerational pedigrees, with a mean sequencing depth of coverage of approximately 36×. We find that Latin American isolates

SUBMITTER: Mooney JA 

PROVIDER: S-EPMC6218714 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature