Claudin-14 Gene Polymorphisms and Urine Calcium Excretion.

ABSTRACT:

Background and objectives

Claudin-16 and -19 are proteins forming pores for the paracellular reabsorption of divalent cations in the ascending limb of Henle loop; conversely, claudin-14 decreases ion permeability of these pores. Single-nucleotide polymorphisms in gene coding for claudin-14 were associated with kidney stones and calcium excretion. This study aimed to explore the association of claudin-14, claudin-16, and claudin-19 single-nucleotide polymorphisms with calcium excretion.

Design, setting, participants, & measurements

We performed a retrospective observational study of 393 patients with hypertension who were naïve to antihypertensive drugs, in whom we measured 24-hour urine calcium excretion; history of kidney stones was ascertained b

SUBMITTER: Arcidiacono T 

PROVIDER: S-EPMC6218816 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature