Kidney Function Decline in Patients with CKD and Untreated Hepatitis C Infection.

ABSTRACT:

Background and objectives

Studies evaluating the role of hepatitis C viral (HCV) infection on the progression of CKD are few and conflicting. Therefore, we evaluated the association of untreated HCV on kidney function decline in patients with stage 3-5 CKD.

Design, setting, participants, & measurements

This retrospective cohort study included members of Kaiser Permanente Southern California and Kaiser Permanente Mid-Atlantic States aged ≥18 years, with incident HCV and CKD diagnoses from January 1, 2004 to December 31, 2014. We used generalized estimating equations to compare the rate of change in eGFR between those with HCV and CKD versus CKD alone, adjusting for covariates. Cox proportional hazards models compared the risk of 25% decrease in eGFR and ESKD (defined as progr

SUBMITTER: Tartof SY 

PROVIDER: S-EPMC6218821 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature