Peripheral Blood B Cell Depletion after Rituximab and Complete Response in Lupus Nephritis.

ABSTRACT:

Background and objectives

Incomplete peripheral blood B cell depletion after rituximab in lupus nephritis might correlate with inability to reduce tubulointerstitial lymphoid aggregates in the kidney, which together could be responsible for inadequate response to treatment. We utilized data from the Lupus Nephritis Assessment with Rituximab (LUNAR) study to characterize the variability of peripheral blood B cell depletion after rituximab and assess its association with complete response in patients with lupus nephritis.

Design, setting, participants, & measurements

We analyzed 68 participants treated with rituximab. Peripheral blood B cell depletion was defined as 0 cells/µl, termed "complete peripheral depletion," assessed over 78 weeks. Logistic regression was used

SUBMITTER: Gomez Mendez LM 

PROVIDER: S-EPMC6218830 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature