Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease.

ABSTRACT:

Background and objectives

Both increased arterial stiffness and vascular endothelial dysfunction are evident in patients with autosomal dominant polycystic kidney disease, even early in the course of the disease when kidney function in preserved. Vascular dysfunction in autosomal dominant polycystic kidney disease is thought to be related to vascular oxidative stress and inflammation, but direct evidence is lacking.

Design, setting, participants, & measurements

We assessed carotid-femoral pulse-wave velocity (arterial stiffness) and brachial artery flow-mediated dilation (vascular endothelial function) in participants with early-stage autosomal dominant polycystic kidney disease (eGFR≥60 ml/min per 1.73 m²) and a history of controlled hypertension and in healthy c

SUBMITTER: Nowak KL 

PROVIDER: S-EPMC6218833 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature