Effect of Treatment of Metabolic Acidosis on Vascular Endothelial Function in Patients with CKD: A Pilot Randomized Cross-Over Study.

ABSTRACT:

Background and objectives

We examined the effect of alkali replacement for metabolic acidosis on vascular endothelial function in patients with CKD.

Methods

We performed a pilot, prospective, open-label 14-week crossover study examining the effect of oral sodium bicarbonate treatment on vascular function in 20 patients with an eGFR of 15-44 ml/min per 1.73 m² with low serum bicarbonate levels (16-21 mEq/L). Each period was 6 weeks in duration with a 2-week washout period in between. Patients were treated to goal serum bicarbonate of ≥23 mEq/L. The primary end point was change in brachial artery flow-mediated dilation (FMD) between treatment and control conditions. Secondary end points included changes in markers of inflammation, bone turnover, mineral metabolism,

SUBMITTER: Kendrick J 

PROVIDER: S-EPMC6218835 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature