Triple therapy in the management of chronic obstructive pulmonary disease: systematic review and meta-analysis.

ABSTRACT:

Objective

To compare the rate of moderate to severe exacerbations between triple therapy and dual therapy or monotherapy in patients with chronic obstructive pulmonary disease (COPD).

Design

Systematic review and meta-analysis of randomised controlled trials.

Data sources

PubMed, Embase, Cochrane databases, and clinical trial registries searched from inception to April 2018.

Eligibility criteria

Randomised controlled trials comparing triple therapy with dual therapy or monotherapy in patients with COPD were eligible. Efficacy and safety outcomes of interest were also available.

Data extraction and synthesis

Data were collected independently. Meta-analyses were conducted to calculate rate ratios, hazard ratios, risk ratios, and mean differences with 95% c

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC6218838 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature