Platelet Microparticles Mediate Glomerular Endothelial Injury in Early Diabetic Nephropathy.

ABSTRACT:

Background

Glomerular endothelium dysfunction, which plays a crucial role in the pathogenesis of early diabetic nephropathy, might be caused by circulating metabolic abnormalities. Platelet microparticles, extracellular vesicles released from activated platelets, have recently emerged as a novel regulator of vascular dysfunction.

Methods

We studied the effects of platelet microparticles on glomerular endothelial injury in early diabetic nephropathy in rats with streptozotocin-induced diabetes and primary rat glomerular endothelial cells. Isolated platelet microparticles were measured by flow cytometry.

Results

Plasma platelet microparticles were significantly increased in diabetic rats, an effect inhibited in aspirin-treated animals. In cultured glomerular endothelial

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6218868 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature