Crystal structure of the thalidomide analog (3aR*,7aS*)-2-(2,6-dioxopiperidin-3-yl)hexa-hydro-1H-iso-indole-1,3(2H)-dione.

ABSTRACT: The title compound, C₁₃H₁₆N₂O₄, crystallizes in the monoclinic centrosymmetric space group, P2₁/c, with four mol-ecules in the asymmetric unit, thus there is no crystallographically imposed symmetry and it is a racemic mixture. The structure consists of a six-membered unsaturated ring bound to a five-membered pyrrolidine-2,5-dione ring N-bound to a six-membered piperidine-2,6-dione ring and thus has the same basic skeleton as thalidomide, except for the six-membered unsaturated ring substituted for the aromatic ring. In the crystal, the mol-ecules are linked into inversion dimers by R ² ₂(8) hydrogen bonding involving the N-H group. In addition, there are bifurcated C-H⋯O inter-actions involvi

SUBMITTER: Hijji Y 

PROVIDER: S-EPMC6218906 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature